Lee debuted on the small screen through MBC sitcom series "Here He Comes," in October 2008. His global popularity, however, stems from his 11-year long appearance as one of the main hosts on SBS variety show "Running Man," (2010-), earning him the nickname "Prince of Asia." The actor has consistently starred in small and large roles over the years, in both films and on television. He quit "Running Man," in 2021 citing health reasons. Since leaving the show he has featured in films such as "Sinkhole," (2021), "A Year-end Medley," (2021) and "The Pirates: The Last Royal Treasure," (2022). TvN drama series "The Killer's Shopping List," marked his first return to the small screen in four years since "Live," (2018) on tvN.